SENTINEL-Chain: a blockchain-integrated privacy-preserving framework for secure healthcare data publishing - Report - MDSpire

SENTINEL-Chain: a blockchain-integrated privacy-preserving framework for secure healthcare data publishing

  • By

  • Nagaraj Segar

  • Vijayarajan Vijayan

  • June 9, 2026

  • 0 min

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Clinical Report: SENTINEL-Chain: A Blockchain-Based Framework for Secure and Privacy-Respecting Healthcare Data Sharing

Overview

SENTINEL-Chain is a blockchain-integrated framework designed to enhance the privacy and utility of electronic health records (EHRs) during data sharing. It achieves a privacy score of 79.9% and utility of 98.2%, outperforming existing methods significantly.

Background

The digitization of healthcare has led to vast amounts of electronic health records (EHRs), which are essential for research and analytics but pose significant privacy risks. Traditional privacy-preserving methods often compromise the analytical utility of data, making it challenging to maintain the integrity of clinical correlations. Addressing these issues is crucial for advancing healthcare analytics while ensuring patient confidentiality.

Data Highlights

MetricScore
Privacy Score79.9%
Utility Score98.2%
Combined Score178.1%
Correlation Fidelity (Claim Amount)99.9%
Correlation Fidelity (Length of Stay)99.6%
Correlation Fidelity (Age)99.7%
Correlation Fidelity (Severity Indices)99.1%
Transaction Processing9,988 transactions in 101 blocks
Throughput3,600 records/second

Key Findings

  • SENTINEL-Chain combines six privacy mechanisms to enhance data sharing security.
  • It achieves a combined privacy and utility score that exceeds existing baselines by 4%-95%.
  • The framework demonstrates 100% resistance to record linkage attacks.
  • Correlation fidelity for key metrics remains above 99%.
  • Smart contract gas estimation indicates a per-record registration cost of 61,895 gas units.

Clinical Implications

The SENTINEL-Chain framework provides a robust solution for secure EHR sharing, balancing privacy and utility effectively. Its high correlation fidelity ensures that data remains clinically relevant for predictive modeling and analysis.

Conclusion

SENTINEL-Chain represents a significant advancement in the secure sharing of healthcare data, addressing critical gaps in privacy and utility while leveraging blockchain technology.

Related Resources & Content

  1. Frontiers in Digital Health, 2026 -- Secure healthcare data management using federated learning, blockchain, and explainable artificial intelligence: a systematic review
  2. Journal of Medical Internet Research (JMIR), 2026 -- Blockchain-Enabled Self-Sovereign Identity Applications in Health Care: Scoping Review
  3. npj Digital Medicine, 2025 -- A user-driven consent platform for health data sharing in digital health applications
  4. Journal of Medical Internet Research (JMIR), 2026 -- Rethinking Trust in Synthetic Health Data: Lessons From 7 European Research Initiatives
  5. HTI-1 Final Rule - ONC - Office of the National Coordinator for Health Information Technology
  6. Privacy preservation in blockchain-based healthcare data sharing: A systematic review - PMC
  7. NIST Releases Version 2.0 of Landmark Cybersecurity Framework | NIST
  8. HTI-1 Final Rule - ONC - Office of the National Coordinator for Health Information Technology
  9. Privacy preservation in blockchain-based healthcare data sharing: A systematic review - PMC
  10. NIST Releases Version 2.0 of Landmark Cybersecurity Framework | NIST

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