Clinical Report: Association of Platelet Metrics with Coronary Artery Lesions in Children Diagnosed with Kawasaki Disease

Overview

This study investigates the correlation between platelet levels and coronary artery lesions in children with Kawasaki disease (KD). The findings indicate that higher platelet parameters are associated with the presence of coronary artery lesions in this population.

Background

Kawasaki disease is a significant cause of acquired heart disease in children, with coronary artery lesions being a severe complication. The incidence of these lesions can lead to long-term cardiovascular issues, making it crucial to identify risk factors and potential biomarkers for early intervention.

Data Highlights

Key Findings

• Platelet parameters (PLT, MPV, PCT, PDW) were significantly higher in KD patients compared to healthy controls (all P < 0.05).
• The lesion group exhibited higher platelet parameters than the non-lesion group (all P < 0.05).
• The Harada score was significantly higher in the lesion group compared to the non-lesion group (P < 0.05).
• Multivariate binary logistic regression analysis showed significant correlations between platelet metrics and coronary artery lesions (P < 0.05).
• Coronary artery lesions can occur in 15%-25% of untreated KD cases, leading to serious cardiovascular complications.

Clinical Implications

The study suggests that platelet parameters may serve as potential biomarkers for assessing the risk of coronary artery lesions in children with Kawasaki disease. Monitoring these metrics could aid in the clinical management and risk stratification of affected patients.

Conclusion

The findings indicate a close association between platelet levels and coronary artery lesions in children with Kawasaki disease. Further research is warranted to validate these parameters as clinical tools for risk assessment.

Related Resources & Content

1. Frontiers in Pediatrics, 2026 -- A predictive model and nomogram for coronary artery injury in Kawasaki disease based on laboratory indicators: a retrospective study
2. Frontiers in Pediatrics, 2026 -- A predictive model for long-term coronary artery lesion risk in Kawasaki disease
3. JAMA Network Open -- Validation of a 2-Gene Blood Test for Kawasaki Disease in Febrile Children
4. Update on Diagnosis and Management of Kawasaki Disease: A Scientific Statement From the American Heart Association
5. JAMA Network Open — A Step Forward Toward Improved Kawasaki Disease Diagnosis
6. Update on Diagnosis and Management of Kawasaki Disease: A Scientific Statement From the American Heart Association
7. Low platelet count, immunoglobulin resistance, and coronary artery involvement in Kawasaki disease | Pediatric Research