Impact of Estimated Glomerular Filtration Rate on In-Hospital Mortality Among Heart Failure Patients

Overview

This study investigates the independent prognostic impact of estimated glomerular filtration rate (eGFR) on in-hospital mortality among heart failure patients.

Background

Heart failure (HF) is a prevalent condition with significant morbidity and mortality, and renal dysfunction is a common comorbidity that complicates its management. This study aims to clarify the independent association of eGFR with mortality risk in this population.

Data Highlights

Key Findings

• In-hospital mortality rates increased progressively across eGFR strata.
• eGFR 45–59 mL/min/1.73 m² was associated with an OR of 1.27 for in-hospital mortality.
• eGFR 30–44 mL/min/1.73 m² was associated with an OR of 1.36 for in-hospital mortality.
• Patients with eGFR < 60 mL/min/1.73 m² had a 37% higher risk of in-hospital mortality (OR 1.37).
• A significant interaction was observed between eGFR and NYHA functional class, amplifying mortality risk in classes III and IV.
• RCS analysis indicated a nonlinear relationship between eGFR and in-hospital mortality risk, with a critical inflection point at approximately 60 mL/min/1.73 m².

Clinical Implications

The findings indicate that eGFR is associated with in-hospital mortality risk in hospitalized heart failure patients.

Conclusion

Reduced eGFR is a significant independent predictor of in-hospital mortality in heart failure patients.

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