Clinical Report: Association of Serum Calcium and Asprosin Levels in Older Adults

Overview

This study investigates the relationship between serum calcium and asprosin levels in elderly patients with type 2 diabetes mellitus (T2D). It identifies significant associations between these biomarkers and various metabolic indicators.

Background

The increasing prevalence of type 2 diabetes mellitus (T2D) among the elderly poses significant public health challenges, particularly in managing metabolic disorders and cardiovascular risks. Calcium homeostasis and adipokine metabolism are critical factors in the progression of T2D and its complications.

Data Highlights

Key Findings

• Serum asprosin levels increased progressively across serum calcium tertiles.
• Statistically significant associations were found between serum calcium and HDL-C, uric acid, asprosin, and creatinine.
• In multivariable linear regression, creatinine and asprosin were independently associated with serum calcium levels.
• A significant positive correlation was observed between serum asprosin and total calcium.

Clinical Implications

The findings suggest that monitoring serum asprosin and calcium levels may be important in managing elderly patients with T2D. Understanding these associations could inform clinical strategies aimed at addressing metabolic and cardiovascular risks in this population.

Conclusion

The study establishes a significant independent association between serum asprosin and calcium levels in elderly patients with T2D.

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