Restarting Medications After Deprescribing in Adults Discharged From Hospital to Skilled Nursing - Report - MDSpire

Restarting Medications After Deprescribing in Adults Discharged From Hospital to Skilled Nursing

  • By

  • Thomas J. Reese

  • Sandra F. Simmons

  • Eduard E. Vasilevskis

  • Emily K. Hollingsworth

  • Matthew S. Shotwell

  • Amanda S. Mixon

  • June 8, 2026

  • 0 min

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Clinical Report: Reinitiating Medications Following Deprescribing in Adults

Overview

This report examines the frequency and factors associated with reinitiating medications after deprescribing in older adults transitioning from hospital to skilled nursing facilities (SNFs). The findings indicate that medication restarts are common and highlight the need for improved care coordination during transitions.

Background

Polypharmacy is prevalent among older adults, with significant risks associated with potentially inappropriate medications (PIMs). Deprescribing aims to reduce medication burden and associated harms, yet the durability of these interventions and the factors influencing medication reinitiation remain underexplored. Understanding these dynamics is crucial for enhancing patient safety during transitions from hospital to SNF care.

Data Highlights

No specific numerical data was provided in the source material.

Key Findings

  • Polypharmacy affects 39% to 65% of community-dwelling older adults and 45% of hospitalized patients.
  • Up to 70% of hospitalized older adults receive at least one potentially inappropriate medication.
  • Deprescribing interventions can reduce total medications and PIM use without increasing adverse drug events.
  • Medication restarts may indicate inadequate patient education or unresolved symptoms requiring treatment.
  • Transitions from hospital to SNF are critical periods for medication changes, often reversed due to communication breakdowns.

Clinical Implications

Healthcare providers should be aware of the high rates of medication reinitiation following deprescribing during transitions to skilled nursing facilities. Enhanced communication and patient education are essential to ensure safe medication management during these transitions.

Conclusion

The study underscores the importance of understanding medication restart patterns after deprescribing to improve patient outcomes during care transitions. Further research is needed to identify effective strategies for sustaining deprescribing benefits.

Related Resources & Content

  1. American Geriatrics Society, PMC, 2023 -- Updated AGS Beers Criteria® for potentially inappropriate medication use in older adults
  2. STOPP/START criteria for potentially inappropriate prescribing in older people: version 3, PMC, 2023
  3. DEPARTMENT OF HEALTH & HUMAN SERVICES, CMS, 2025 -- QSO-25-14-NH revised memorandum
  4. American Diabetes Association, 2025 -- Standards of Care in Diabetes
  5. conexiant — Cognition-Affecting Drugs Often Start in Acute Care
  6. Stat News — RFK Jr.’s antidepressant deprescribing push gets one thing right — and others dangerously wrong
  7. Drugs - Real World Outcomes — Examination of Long-Term and High-Dose Proton Pump Inhibitor Usage: A Cross-Sectional Analysis in Six Aged Care Facilities in South Australia
  8. Drugs - Real World Outcomes — Assessment of Inappropriate Medication Use Among Frail Elderly Individuals in Long-Term Care: A Retrospective Review of Medical Records
  9. Cognition-Affecting Drugs Often Start in Acute Care
  10. RFK Jr.’s antidepressant deprescribing push gets one thing right — and others dangerously wrong
  11. Examination of Long-Term and High-Dose Proton Pump Inhibitor Usage
  12. American Geriatrics Society 2023 updated AGS Beers Criteria® for potentially inappropriate medication use in older adults - PMC
  13. STOPP/START criteria for potentially inappropriate prescribing in older people: version 3 - PMC
  14. DEPARTMENT OF HEALTH & HUMAN SERVICES
  15. SOM - Appendix PP
  16. 13. Older Adults: Standards of Care in Diabetes—2025 | Diabetes Care | American Diabetes Association
  17. Electronic Health Record Intervention and Deprescribing for Older Adults: A Randomized Clinical Trial - PubMed
  18. A Pharmacist Consultant Service for Deprescribing Opioids and Benzodiazepines in Older Adults: A Cluster Randomized Trial | Geriatrics | JAMA Network Open | JAMA Network
  19. Efficacy and safety of antihypertensive drugs deprescribing in older adults: A systematic review and meta-analysis of randomized controlled trials - PubMed
  20. PReventing Injury in Skilled nursing facilities through optimizing Medications (PRISM), a protocol for a cluster randomized trial to reduce injurious falls in post-acute care | Trials | Full Text
  21. Deprescribing To Reduce Medication Harms in Older Adults - Making Healthcare Safer IV - NCBI Bookshelf

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