Pain-free survival after endoscopic neurotomy versus radiofrequency ablation of the C2 dorsal root ganglion for cervicogenic headache: a real-world comparison study - Report - MDSpire

Pain-free survival after endoscopic neurotomy versus radiofrequency ablation of the C2 dorsal root ganglion for cervicogenic headache: a real-world comparison study

  • By

  • Yunjian Huang

  • Shiyun Xu

  • Siyi Liu

  • Wancheng Zheng

  • Zaiying Jiang

  • Xiangdong Wan

  • Xiangyu Zhang

  • Tao Du

  • Guang Lu

  • Bing Ni

  • Hongwei Zhu

  • June 8, 2026

  • 0 min

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Long-term Pain Relief Outcomes of Endoscopic Neurotomy Compared to Radiofrequency Ablation for C2 Dorsal Root Ganglion in Cervicogenic Headache: A Real-World Analysis

Overview

This study compares the long-term pain relief outcomes of endoscopic neurotomy (EN) and radiofrequency ablation (RFA) targeting the C2 dorsal root ganglion in patients with cervicogenic headache (CEH). Results indicate that while both treatments improve pain and quality of life, EN offers a significantly longer pain-free duration compared to RFA.

Background

Cervicogenic headache (CEH) is a prevalent secondary headache that often results in significant pain and functional impairment. Traditional treatments, including pharmacotherapy and physical therapy, frequently provide inadequate long-term relief. This study addresses the need for more durable interventions by comparing EN and RFA, both of which target the C2 dorsal root ganglion, a key nociceptive hub in CEH.

Data Highlights

{'P-values': "Ensure consistent formatting and clarify 'NS' for non-significant results."}

Key Findings

{'NRS and EQ-5D-5L': 'Add specific statistical values for improvements at 3 months.'}

Clinical Implications

{'EN invasiveness': 'Provide more detail on how invasiveness affects treatment recommendations.'}

Conclusion

{'patient evaluation': "Emphasize the need for careful evaluation due to EN's invasive nature."}

Related Resources & Content

  1. Frontiers | Pain-free survival after endoscopic neurotomy versus radiofrequency ablation of the C2 dorsal root ganglion for cervicogenic headache: a real-world comparison study
  2. The International Classification of Headache Disorders - ICHD-3
  3. Efficacy of interventional treatment strategies for managing patients with cervicogenic headache: a systematic review - PMC
  4. Pain Medicine — Evaluation of a novel nerve ablation technique to relieve lower back pain: a cadaveric feasibility pilot study
  5. Pain Medicine — Efficacy of Basivertebral Nerve Radiofrequency Ablation in Managing Vertebrogenic Low Back Pain: One-Year Outcomes from a Prospective Real-World Cohort Analysis
  6. Frontiers in Pain Research — Clinical study of the preventive effect of pulsed radiofrequency and continuous epidural block on postherpetic neuralgia: A randomized controlled trial
  7. Pain Medicine — The Q2 approach for percutaneous peripheral neuromodulation stimulator implantation targeting the C2 dorsal root ganglion at the C2 lamina for treatment of intractable headache: a technical note
  8. The International Classification of Headache Disorders - ICHD-3
  9. Efficacy of interventional treatment strategies for managing patients with cervicogenic headache: a systematic review - PMC
  10. Frontiers | Pain-free survival after endoscopic neurotomy versus radiofrequency ablation of the C2 dorsal root ganglion for cervicogenic headache: a real-world comparison study

Original Source(s)

Pain-free survival after endoscopic neurotomy versus radiofrequency ablation of the C2 dorsal root ganglion for cervicogenic headache: a real-world comparison study

  • by Yunjian Huang, Shiyun Xu, Siyi Liu, Wancheng Zheng, Zaiying Jiang, Xiangdong Wan, Xiangyu Zhang, Tao Du, Guang Lu, Bing Ni, Hongwei Zhu

  • June 8, 2026

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