Correction: Phase I/II, open-label, multicenter study of durvalumab in combination with tremelimumab in pediatric patients with advanced solid tumors - Report - MDSpire

Correction: Phase I/II, open-label, multicenter study of durvalumab in combination with tremelimumab in pediatric patients with advanced solid tumors

  • By

  • Darren Hargrave

  • Lynley V. Marshall

  • Nicolas André

  • Julie Krystal

  • Brian H. Ladle

  • Karen A. Robbins

  • Stephan Hois

  • Jon Armstrong

  • Sarah Donegan

  • June 9, 2026

  • 0 min

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Clinical Report: Erratum on Phase I/II Study of Durvalumab and Tremelimumab

Overview

This report addresses a correction in the Phase I/II study evaluating durvalumab and tremelimumab in pediatric patients with advanced solid tumors. The erratum highlights misalignment in data presentation and missing footnotes in the original publication.

Background

The study of durvalumab and tremelimumab is significant as it explores dual checkpoint blockade in pediatric patients with relapsed/refractory solid tumors. Accurate data representation is crucial for the interpretation of clinical trial results, which can impact future research and treatment protocols in this vulnerable population.

Data Highlights

Correction Details
Misalignment of numerical values in Table 1
Missing footnote for histology terms

Key Findings

  • Correction of misaligned numerical values in Table 1.
  • Missing footnote regarding histology terms was identified.
  • ETRAN, MPNST, and UCNT were defined in the context of tumor types.
  • The original article has been updated to reflect these corrections.

Clinical Implications

Clinicians should refer to the corrected data for accurate information regarding the study outcomes. Ensuring the integrity of clinical trial data is essential for guiding treatment decisions in pediatric oncology.

Conclusion

The erratum serves to clarify previous inaccuracies in the study's data presentation, reinforcing the importance of precise reporting in clinical research.

Related Resources & Content

  1. Hargrave D et al., Frontiers in Oncology, 2026 -- Erratum: Phase I/II Multicenter Study Evaluating Durvalumab and Tremelimumab in Pediatric Patients with Advanced Solid Tumors
  2. Blood Cancer Journal — Correction: Outcomes of Blinatumomab in Children with Relapsed/Refractory Acute Lymphoblastic Leukemia: Findings from the RIALTO Expanded Access Study
  3. Blood Cancer Journal — Author Correction: Blinatumomab in pediatric patients with relapsed/refractory acute lymphoblastic leukemia: results of the RIALTO trial, an expanded access study
  4. The ASCO Post — Study Finds Durvalumab Retreatment Active in Some Patients With Advanced Solid Tumors Retreatment With Durvalumab Related Articles
  5. Frontiers | Phase I/II, open-label, multicenter study of durvalumab in combination with tremelimumab in pediatric patients with advanced solid tumors
  6. The safety and efficacy of immune checkpoint blockade in children, adolescents, and young adults: A systematic review and meta-analysis - ScienceDirect
  7. The current status of immune checkpoint inhibitors in pediatric CNS tumors: a systematic review with a representative case of CMMRD-associated glioma - PubMed
  8. Pediatric Central Nervous System Cancers, Version 2.2025, NCCN Clinical Practice Guidelines In Oncology | CoLab
  9. Endocrine-Related Adverse Conditions in Pediatric Patients Treated with Immune Checkpoint Inhibitors: A Position Statement from the Clinical Practice Committee of the European Society for Pediatric Endocrinology - PMC

Original Source(s)

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