Plasma cytokine profiles in breast cancer patients and their association with therapeutic response in Peru: a prospective cohort study - Report - MDSpire
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Plasma cytokine profiles in breast cancer patients and their association with therapeutic response in Peru: a prospective cohort study
Clinical Report: Cytokine Profiles in Plasma of Breast Cancer Patients in Peru
Overview
Expand on the role of FGF-BASIC in treatment outcomes and its comparison with other cytokines.
Background
Breast cancer is the most prevalent malignancy among women globally and in Peru, with significant morbidity and mortality. Understanding the role of cytokines in breast cancer can provide insights into tumor behavior and treatment resistance, which is crucial for improving patient outcomes. This study addresses the gap in knowledge regarding cytokine profiles in Latin American populations, particularly in Peru.
Data Highlights
Cytokine
Association with pCR
Clinical Response
FGF BASIC
RR = 0.9779; 95% CI 0.9573–0.9989; p=0.0392
Independently associated
PDGF BB
-
Independently associated
IL-12 P40
-
Independently associated
IL-8
-
Decreased levels related to clinical response
Key Findings
Cytokine concentration differences were observed between breast cancer molecular subtypes.
Lower levels of FGF BASIC were necessary to increase the relative risk of achieving pathological complete response (pCR).
Decreased levels of PDGF BB, SDF-1, IL-12 P40, and IL-8 were associated with improved clinical response to treatments.
Multivariable analyses indicated that FGF-BASIC, PDGF-BB, and IL-12 P40 were independently associated with clinical response.
This study provides evidence of the relevance of cytokine profiles in predicting treatment outcomes in breast cancer patients.
Clinical Implications
The findings suggest that measuring specific cytokines, particularly FGF-BASIC, could aid in predicting treatment responses in breast cancer patients. This may help clinicians in stratifying patients for more personalized treatment approaches, although further validation in larger cohorts is necessary.
Conclusion
This study highlights the potential of plasma cytokine profiles as biomarkers for treatment response in breast cancer, emphasizing the need for further research in diverse populations to validate these findings.
by Jose M. Vela-Ruiz, Zaida Morante, Yomali Ferreyra, Marco A. Galvez-Villanueva, Fernando Valencia, J. Jhanina Campos-Tineo, Mariana Callapiña De Paz, Ariana Alessandra Córdova-Salazar, Pool Marcos-Carbajal, Joan M. Moreno Lujan, Andy R. Pantoja Lazaro, Laura G. Escobar Caipo, Gustavo A. Flores Trujillo, Teresa N. Cusma Quintana, Jhony A. De La Cruz-Vargas, Henry L. Gomez, Alonso Soto
