Motivational neurobehavioral abnormalities under a naturalistic goal-conflict task in patients with premenstrual dysphoric disorder
By
Yulia Lerner
Michael Krasnoshtein
Miki Bloch
Michal Tevet
Maayan Doron
Tal Gonen
Talma Hendler
Oren Tene
June 8, 2026
Clinical Scorecard: Neurobehavioral Motivational Deficits in Patients with Premenstrual Dysphoric Disorder During a Naturalistic Goal-Conflict Task
At a Glance
Category Detail
Condition Key Mechanisms Dopaminergic mesolimbic pathway dysfunction affecting reward processing and motivation. Target Population Care Setting
Key Highlights
Participants with PMDD showed reduced approach behavior under low goal-conflict conditions. Greater symptom severity in PMDD was linked to lower approach behavior under high goal-conflict conditions. Diminished activation in the ventral striatum and ventral tegmental area was observed in PMDD during high goal-conflict tasks. Guideline-Based Recommendations
Diagnosis
Assessment of symptom severity using the Premenstrual Tension Syndrome Observer Rating Scale (PMTS-OR). Management
Consideration of therapeutic targets in reward processing pathways. Monitoring & Follow-up
Monitoring of motivational behavior and symptom severity during the luteal phase. Risks
Potential for impaired goal-directed behavior and reduced work productivity in PMDD. Patient & Prescribing Data
Women diagnosed with Premenstrual Dysphoric Disorder.
Focus on addressing motivational deficits linked to hormonal fluctuations.
Clinical Best Practices
Utilize fMRI to assess neural activity related to motivation in PMDD. Incorporate evaluation of dopamine-related pathways in treatment planning. Related Resources & Content
