Beyond aesthetic outcomes: psychodermatological benefits of botulinum toxin treatment in the upper facial third. A narrative review - Scorecard - MDSpire

Beyond aesthetic outcomes: psychodermatological benefits of botulinum toxin treatment in the upper facial third. A narrative review

  • By

  • Álvaro Loewen

  • Sabina Aranda-Guerrero

  • Kazuhiro Tajima-Pozo

  • June 9, 2026

  • 0 min

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Clinical Scorecard: Exploring the Psychological Advantages of Botulinum Toxin Therapy in the Upper Face: A Narrative Review on Psychodermatological Effects

At a Glance

CategoryDetail
ConditionPsychodermatological effects of Botulinum toxin type A (BoNT-A) treatment
Key MechanismsInfluence on emotional processing via the skin-brain axis and facial feedback hypothesis
Target PopulationPatients seeking aesthetic treatment for dynamic wrinkles in the upper facial third
Care SettingAesthetic dermatology

Key Highlights

  • BoNT-A is associated with reductions in depressive and anxiety symptoms.
  • Improvements in self-perception and social functioning observed post-treatment.
  • Inhibition of facial muscles modulates signaling to limbic structures.
  • Neuroimaging shows reduced amygdala activation after treatment.
  • Caution advised in patients with body dysmorphic disorder.

Guideline-Based Recommendations

Diagnosis

  • Consider psychological assessments in patients receiving BoNT-A.

Management

  • Use BoNT-A as a complementary intervention within a biopsychosocial framework.

Monitoring & Follow-up

  • Monitor for psychological outcomes post-treatment.

Risks

  • Potential risks in patients with underlying psychiatric disorders, particularly body dysmorphic disorder.

Patient & Prescribing Data

Individuals seeking aesthetic improvements in the upper facial area.

BoNT-A may enhance emotional regulation and affective symptoms.

Clinical Best Practices

  • Conduct thorough psychological evaluations prior to treatment.
  • Integrate psychodermatological considerations into treatment planning.
  • Encourage multidisciplinary approaches involving mental health professionals.

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