Pharmacological ZO-1 agonist treatment attenuates ammonia nitrogen stress-induced mucosal inflammation and intestinal barrier failure in Leiocassis longirostris
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By
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Senyue Liu
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Yang Feng
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Chengyan Mou
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Lu Zhang
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Yuanliang Duan
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Zhipeng Huang
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Han Zhao
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Jian Zhou
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Jun Du
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Qiang Li
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Yongqiang Deng
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June 8, 2026
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Clinical Scorecard: Treatment with ZO-1 Agonist Mitigates Mucosal Inflammation and Intestinal Barrier Dysfunction Induced by Ammonia Nitrogen Stress in Leiocassis longirostris
At a Glance
| Category | Detail |
|---|
| Condition | |
| Key Mechanisms | Ineffective transcriptional compensation and ZO-1 stabilization (ensure direct sourcing). |
| Target Population | |
| Care Setting | |
Key Highlights
- Ammonia exposure causes inflammatory cell infiltration and barrier disruption (source needed).
- ZO-1 acts as a master scaffolding protein essential for tight junction assembly (source needed).
- Pharmacological stabilization of ZO-1 reduces mucosal inflammatory damage (source needed).
- Transcriptional upregulation of tight junction components does not lead to functional protein assembly (source needed).
- Restoration of the extracellular matrix-focal adhesion pathway contributes to mucosal integrity (source needed).
Guideline-Based Recommendations
Diagnosis
Management
- Use of ZO-1 agonist to stabilize intestinal barrier function (ensure direct sourcing).
Monitoring & Follow-up
Risks
Patient & Prescribing Data
ZO-1 stabilization may enhance intestinal mucosal resilience under ammonia stress (ensure direct sourcing).
Clinical Best Practices
- Implement strategies to maintain water quality and minimize ammonia levels in aquaculture (ensure direct sourcing).
- Monitor fish health regularly to detect early signs of mucosal dysfunction (ensure direct sourcing).
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