“Double-hit” precipitates fulminant cardiac dysfunction in a child with homozygous CAP2 variant: a case report
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By
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Zhenhui Pan
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Jiaojiao Wan
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Kaiyu Zhou
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Min Tan
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Yifei Li
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June 9, 2026
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Clinical Scorecard: Severe Cardiac Dysfunction Induced by Dual Factors in a Pediatric Patient with Homozygous CAP2 Mutation: A Case Study
At a Glance
| Category | Detail |
|---|
| Condition | |
| Key Mechanisms | Homozygous loss-of-function CAP2 variant and respiratory viral infection. |
| Target Population | |
| Care Setting | |
Key Highlights
- First report of homozygous CAP2 c.551G > A variant in pediatric DCM.
- Respiratory viral infection identified as a trigger for fulminant cardiac dysfunction.
- Sustained intensive therapies reversed ventricular remodeling.
Guideline-Based Recommendations
Diagnosis
- Consider genetic screening in children with unexplained cardiac malformation or family history of consanguinity.
Management
- Implement intensive therapies for ventricular remodeling in cases of fulminant cardiac dysfunction.
Monitoring & Follow-up
- Monitor for signs of respiratory viral infections in known DCM patients.
Risks
- Infection can exacerbate cardiac dysfunction in genetically predisposed individuals.
Patient & Prescribing Data
Children with genetic variants associated with DCM.
Intensive therapies can provide clinically significant functional benefits.
Clinical Best Practices
- Prioritize genetic screening in pediatric patients with unexplained cardiac symptoms.
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