Repeated-dose toxicity and immunogenicity evaluation of norovirus P particle-based rotavirus vaccine in juvenile cynomolgus monkeys - Scorecard - MDSpire

Repeated-dose toxicity and immunogenicity evaluation of norovirus P particle-based rotavirus vaccine in juvenile cynomolgus monkeys

  • By

  • Wei Pan

  • Yingjie Cheng

  • Xiaojing Shi

  • Yunxiang Chen

  • Cong Xu

  • Zhengbiao Yang

  • Qijiong Lu

  • Lei Wen

  • Fang Liu

  • Tingli Bian

  • Li Qin

  • Shuizhen Pan

  • Ying Chen

  • Changwei Wu

  • Lijiang Zhang

  • Hongzhong Yang

  • June 9, 2026

  • 0 min

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Clinical Scorecard: Assessment of Repeated-Dose Toxicity and Immunogenic Response to Norovirus P Particle-Based Rotavirus Vaccine in Young Cynomolgus Monkeys

At a Glance

CategoryDetail
Condition
Key MechanismsBivalent rotavirus subunit candidate vaccine PP-P[6]/P[8]-VP8 Mix based on norovirus P particles, designed to enhance immunogenicity.
Target Population
Care Setting

Key Highlights

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Guideline-Based Recommendations

Diagnosis

    Management

      Monitoring & Follow-up

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      Risks

        Patient & Prescribing Data

        Current vaccines include oral live-attenuated vaccines with variable efficacy based on country mortality levels; efficacy data should be detailed.

        Clinical Best Practices

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        Related Resources & Content

        Original Source(s)

        Repeated-dose toxicity and immunogenicity evaluation of norovirus P particle-based rotavirus vaccine in juvenile cynomolgus monkeys

        • by Wei Pan, Yingjie Cheng, Xiaojing Shi, Yunxiang Chen, Cong Xu, Zhengbiao Yang, Qijiong Lu, Lei Wen, Fang Liu, Tingli Bian, Li Qin, Shuizhen Pan, Ying Chen, Changwei Wu, Lijiang Zhang, Hongzhong Yang

        • June 9, 2026

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