Cellular expression domains of type 3 deiodinase in the meninges, choroid plexus, tanycytes and barrier tissues of the brain
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By
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Ye Liu
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Lily Ng
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Hong Liu
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Douglas Forrest
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June 8, 2026
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Clinical Scorecard: Expression Patterns of Type 3 Deiodinase in the Meninges, Choroid Plexus, Tanycytes, and Brain Barrier Tissues
At a Glance
| Category | Detail |
|---|
| Condition | Thyroid hormone regulation in brain development |
| Key Mechanisms | Type 3 deiodinase (DIO3) degrades thyroid hormones, controlling their availability in the brain |
| Target Population | Embryonic and neonatal mice |
| Care Setting | Research laboratory |
Key Highlights
- DIO3 expression is found in non-neuronal cell types at brain barrier interfaces.
- Expression of DIO3 peaks during embryonic and neonatal development.
- DIO3 is detected in the meninges, choroid plexus, tanycytes, and pericytes.
Guideline-Based Recommendations
Diagnosis
Management
Monitoring & Follow-up
Risks
Patient & Prescribing Data
Not applicable; study conducted in mice
DIO3 plays a critical role in neurodevelopment by regulating thyroid hormone levels.
Clinical Best Practices
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