Clinical Scorecard: Effects of Clinical Pharmacist Interventions on the Management and Education of Tacrolimus Therapy for Enhanced Therapeutic Control
At a Glance
Category
Detail
Condition
Management of Tacrolimus in Pediatric Bone Marrow Transplantation
Key Mechanisms
Resolution of Drug-Related Problems (DRPs) and education of caregivers and nursing staff
Target Population
Pediatric patients undergoing bone marrow transplantation
Care Setting
Multihospital setting in Istanbul
Key Highlights
77.1% of identified DRPs were successfully resolved by clinical pharmacists
Proportion of patients within the therapeutic range increased from 52.3% to 84.4% post-intervention
Substantial improvements in pharmacological knowledge among caregivers and nurses
Elevated knowledge levels correlated with tacrolimus stability
Systematic education is essential for optimizing medication levels
Guideline-Based Recommendations
Diagnosis
Regular monitoring of tacrolimus blood concentrations
Management
Incorporation of clinical pharmacists to resolve DRPs and educate caregivers
Monitoring & Follow-up
Therapeutic drug monitoring (TDM) to maintain tacrolimus trough concentrations within 5–20 ng/ml
Risks
Subtherapeutic levels increase risk of acute cellular rejection; supratherapeutic levels lead to toxicities
