Angiosarcoma in a soft tissue sarcoma cohort: real-world patterns and outcomes - Summary - MDSpire

Angiosarcoma in a soft tissue sarcoma cohort: real-world patterns and outcomes

  • By

  • Kübra Canaslan

  • Özge Yetginoğlu

  • Hasan Oğuz Çetinayak

  • Emine Burçin Tuna

  • Tuğba Yavuzşen

  • June 9, 2026

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Objective:

To describe demographic and clinicopathological features, treatment patterns, and survival outcomes of patients with angiosarcoma within a soft tissue sarcoma cohort.

Key Findings:
  • Among 548 soft tissue sarcoma cases, 12 patients (2.2%) had angiosarcoma.
  • Median age was 62 years; older age was noted in cutaneous (69 years) versus visceral (44 years) disease.
  • 75% of patients presented with metastatic/unresectable disease at diagnosis.
  • First-line therapy was paclitaxel-based in 66.7% and anthracycline-based in 33.3%, achieving disease control in 66.7%.
  • Median overall survival was 9.5 months and median first-line progression-free survival was 4.8 months.
Interpretation:

Limitations:
  • Single-center study may limit generalizability.
  • Small sample size of angiosarcoma cases.
Conclusion:

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