To investigate the effects of Chelerythrine on innate immunity and its underlying molecular mechanisms in Caenorhabditis elegans infected with Candida albicans.
Key Findings:
Chelerythrine significantly extended the lifespan of C. elegans infected with C. albicans.
The protective effect was not due to a reduction in intestinal fungal burden.
Chelerythrine activated the FoxO and fatty acid metabolism pathways.
The lifespan-extending effect was abolished in daf-16 and nhr-49 mutants.
Chelerythrine treatment upregulated expression of several FoxO pathway and fatty acid metabolism-related genes.
No direct inhibitory activity of Chelerythrine against various pathogens was observed.
Interpretation:
Limitations:
The study was conducted in a model organism, which may not fully replicate human responses.
The specific mechanisms of action of Chelerythrine in other species remain to be explored.
