Editorial: New Insights on Sialic Acid and Sialylated Glycans in the Tumorigenic Process

To highlight recent insights into the role of sialic acids and sialylated glycans in tumorigenesis.

Hypersialylation in tumors is driven by altered expression of glycosylation enzymes, impacting tumor behavior.
Polysialic acid (polySia) upregulation on immune cells negatively regulates anti-tumor immune responses.
Sialylation inhibition enhances macrophage-mediated phagocytosis of breast cancer cells, improving antibody therapy efficacy.
Adipose tissue influences hypersialylation in ovarian cancer cells, aiding immune evasion.

The editorial does not provide specific data or quantitative results from the studies discussed.
Further research is needed to fully elucidate the mechanisms by which sialylation affects tumor biology.