Pharmacological ZO-1 agonist treatment attenuates ammonia nitrogen stress-induced mucosal inflammation and intestinal barrier failure in Leiocassis longirostris - Summary - MDSpire

Pharmacological ZO-1 agonist treatment attenuates ammonia nitrogen stress-induced mucosal inflammation and intestinal barrier failure in Leiocassis longirostris

  • By

  • Senyue Liu

  • Yang Feng

  • Chengyan Mou

  • Lu Zhang

  • Yuanliang Duan

  • Zhipeng Huang

  • Han Zhao

  • Jian Zhou

  • Jun Du

  • Qiang Li

  • Yongqiang Deng

  • June 8, 2026

  • 0 min

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Objective:

To analyze the pathological and immunological features of ammonia-induced intestinal damage in Leiocassis longirostris and evaluate the potential of stabilizing ZO-1 protein homeostasis.

Key Findings:
  • Ammonia exposure led to inflammatory cell infiltration and disruption of the intestinal epithelial barrier.
  • Transcripts of tight junction components like zo-1 and occludin were upregulated, but protein assembly was disrupted.
  • Pharmacological stabilization of ZO-1 reduced mucosal inflammatory damage and restored tight junction protein localization.
Interpretation:

The study identifies a response where increased mRNA levels do not correspond to functional protein output.

Limitations:
  • The study is limited to Leiocassis longirostris, which may not generalize to other species.
  • The long-term effects of ZO-1 stabilization on fish health were not assessed.
Conclusion:

Stabilizing ZO-1 may enhance intestinal mucosal resilience in aquaculture.

Original Source(s)

Pharmacological ZO-1 agonist treatment attenuates ammonia nitrogen stress-induced mucosal inflammation and intestinal barrier failure in Leiocassis longirostris

  • by Senyue Liu, Yang Feng, Chengyan Mou, Lu Zhang, Yuanliang Duan, Zhipeng Huang, Han Zhao, Jian Zhou, Jun Du, Qiang Li, Yongqiang Deng

  • June 8, 2026

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