“Double-hit” precipitates fulminant cardiac dysfunction in a child with homozygous CAP2 variant: a case report - Summary - MDSpire

“Double-hit” precipitates fulminant cardiac dysfunction in a child with homozygous CAP2 variant: a case report

  • By

  • Zhenhui Pan

  • Jiaojiao Wan

  • Kaiyu Zhou

  • Min Tan

  • Yifei Li

  • June 9, 2026

  • 0 min

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Objective:

To report a case of dilated cardiomyopathy (DCM) in a child with a homozygous CAP2 mutation triggered by a respiratory viral infection.

Key Findings:
  • The patient exhibited severe cardiac dysfunction linked to a homozygous CAP2 mutation.
  • Respiratory viral infection served as a trigger for the patient's cardiac deterioration.
  • The CAP2 mutation disrupts cytoskeletal integrity, impacting cardiac function.
Interpretation:

This case presents a unique instance of DCM in a child with a homozygous CAP2 mutation and highlights the potential role of environmental triggers.

Limitations:
  • The findings are based on a single case study, limiting generalizability.
  • Long-term outcomes and the impact of interventions remain to be fully assessed.
Conclusion:

The case suggests the importance of genetic screening in pediatric patients with unexplained cardiac issues.

Original Source(s)

“Double-hit” precipitates fulminant cardiac dysfunction in a child with homozygous CAP2 variant: a case report

  • by Zhenhui Pan, Jiaojiao Wan, Kaiyu Zhou, Min Tan, Yifei Li

  • June 9, 2026

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