Diagnostic performance of three-dimensional high-resolution anorectal manometry in identifying descending perineal syndrome - Summary - MDSpire

Diagnostic performance of three-dimensional high-resolution anorectal manometry in identifying descending perineal syndrome

  • By

  • Hua Chu

  • You Wang

  • Chunrong Ma

  • Lijun Du

  • June 9, 2026

  • 0 min

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Objective:

To evaluate the diagnostic performance of 3DHRAM in identifying descending perineal syndrome (DPS) specifically in patients with obstructed defecation.

Key Findings:
  • 41.3% of patients presented with DPS on CD.
  • Perineal descent was independently associated with DPS (odds ratio = 1.13, 95% CI 1.03–1.23, P = 0.009).
  • 3DHRAM showed sensitivity of 0.61 and specificity of 0.76 for excessive perineal descent with a cut-off value of 10.5 mm.
  • The best diagnostic performance was achieved when combining perineal descent with rectocele, rectal mucosal prolapse, and dyssynergic pattern, yielding a Youden Index of 0.44.
Interpretation:

3DHRAM has potential as a complementary tool for diagnosing DPS, but further validation is needed.

Limitations:
  • Single-center study may limit generalizability.
  • Retrospective design may introduce selection bias.
  • Small sample size may affect the robustness of findings.
Conclusion:

Future multi-center, prospective studies with larger cohorts are needed to validate findings and define the role of 3DHRAM in diagnosing DPS, emphasizing the importance of generalizability.

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