Middle cerebral artery fenestration presenting with cerebral ischemia: a case report and review of the literature - Summary - MDSpire

Middle cerebral artery fenestration presenting with cerebral ischemia: a case report and review of the literature

  • By

  • Ying Bi

  • Zhifang Li

  • Wenxian Sun

  • Li Zou

  • Huagang Li

  • Bin Mei

  • June 9, 2026

  • 0 min

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Objective:

To report a case of MCA fenestration and conduct a literature review on its association with cerebral ischemia, highlighting its clinical significance.

Key Findings:
  • MCA fenestration is a rare variant that can mimic stenosis.
  • 73.7% of patients had slit-like morphology, more common in AIS than TIA.
  • 57.9% of diagnoses were made via DSA.
  • Mechanical thrombectomy had favorable outcomes in 83.3% of cases with concurrent MCA occlusion.
  • 73.7% of patients achieved favorable outcomes at follow-up.
  • Patient ages ranged from 4 to 85 years.
Interpretation:

MCA fenestration should be considered in differential diagnoses for cerebral ischemia, especially in patients without conventional vascular risk factors, as it may influence management strategies.

Limitations:
  • The study is based on a limited number of cases, which may not represent the broader population.
  • The relationship between MCA fenestration and cerebral ischemia is not fully understood, necessitating further research.
Conclusion:

Multimodal imaging is essential for accurate diagnosis and management of MCA fenestration, emphasizing its role in preventing misdiagnosis.

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