POC1A promotes malignant phenotypes in non-triple-negative breast cancer cell models with EMT- and Wnt/β-catenin-related alterations

To investigate the expression of POC1A in breast cancer and evaluate its potential clinical relevance.

POC1A was significantly upregulated in breast cancer tissues.
High POC1A expression correlated with larger tumor size and advanced clinical stage.
High POC1A expression was identified as a risk factor for poor prognosis (HR = 1.049, P = 0.014).
POC1A knockdown suppressed cell proliferation, migration, and invasion, while overexpression had the opposite effects.
Modulation of POC1A was associated with changes in Wnt/β-catenin signaling and EMT-related markers.

POC1A protein expression was not validated as an independent prognostic factor in the tissue microarray cohort.
Further validation is required to confirm the diagnostic, prognostic, and mechanistic significance of POC1A.

Further investigation is needed to determine the role of POC1A in breast cancer.