Association of serum selenium levels with inflammatory and oxidative stress markers in patients with post-infarction heart failure: an exploratory case-control study supported by in vitro mechanistic evidence - Summary - MDSpire
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Association of serum selenium levels with inflammatory and oxidative stress markers in patients with post-infarction heart failure: an exploratory case-control study supported by in vitro mechanistic evidence
To evaluate the association between serum Selenium levels and clinical biomarkers of inflammation and oxidative stress specifically in post-infarction heart failure patients.
Key Findings:
HF subjects had significantly lower Selenium and SOD levels than controls (p < 0.05).
Increased levels of inflammatory cytokines (TNF-α, IL-6) and oxidative stress marker (MDA) were observed in HF patients (p < 0.05).
Selenium was positively associated with LVEF and negatively associated with inflammatory markers (p < 0.05).
In vitro, Selenium reduced expression of pro-inflammatory and pro-fibrotic genes during stress (p < 0.05).
Heterogeneous distributions of Selenium and oxidative stress markers were noted across HF phenotypes.
Interpretation:
Selenium deficiency is linked to increased inflammatory and oxidative stress in post-infarction heart failure, suggesting its potential role in cardiac injury mechanisms and the need for further investigation.
Limitations:
The study is limited by its retrospective design.
Sample size may restrict the generalizability of findings.
Potential confounding factors were not fully controlled.
Lack of longitudinal data limits the ability to assess causality.
Conclusion:
Selenium deficiency correlates with greater inflammatory and oxidative stress in post-infarction heart failure, warranting further investigation as a potential biomarker and exploring its therapeutic potential.
