Head-to-head evaluation of ChatGPT, DeepSeek, and Perplexity on acid–base disorder case clinical management and drug treatment: Accuracy, domain performance, and response consistency assessment - Summary - MDSpire

Head-to-head evaluation of ChatGPT, DeepSeek, and Perplexity on acid–base disorder case clinical management and drug treatment: Accuracy, domain performance, and response consistency assessment

  • By

  • Moteb Khobrani

  • Asaad Ahmed Asaad Khalil

  • Salman Ashfaq Ahmad

  • Azfar Athar Ishaqui

  • June 8, 2026

  • 0 min

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Objective:

To evaluate the performance of ChatGPT, DeepSeek, and Perplexity on a standardized set of acid-base disturbance cases, focusing on accuracy, domain-specific performance, and consistency of responses, highlighting the significance of these evaluations in medical education.

Key Findings:
  • Performance of LLMs varied across different acid-base disturbance cases, with specific metrics indicating varying levels of accuracy.
  • Accuracy and consistency of responses were evaluated across 510 multiple-choice questions, revealing distinct performance patterns.
  • Subgroup analysis classified cases into metabolic, respiratory, or mixed acid-base disorders, providing insights into model strengths and weaknesses.
Interpretation:

The study highlights the need for context-specific benchmarking of LLMs in medical education, particularly in complex domains like acid-base disorders, and suggests that improved accuracy could enhance learner outcomes.

Limitations:
  • The dataset was derived from a single source, which may limit generalizability and introduce bias.
  • Original clinical case vignettes were not reproduced verbatim due to copyright restrictions, potentially affecting the authenticity of the assessment.
Conclusion:

The study provides insights into the comparative performance of LLMs in managing acid-base disorders, emphasizing the importance of accuracy and consistency in clinical contexts.

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