Adjuvanted inactivated rabies virus-vectored Lassa virus vaccine in healthy adults: a phase 1 trial - Summary - MDSpire

Adjuvanted inactivated rabies virus-vectored Lassa virus vaccine in healthy adults: a phase 1 trial

  • By

  • Justin R. Ortiz

  • Drishya Kurup

  • Adam C. Kaufman

  • Sabrine Ben Hamed

  • Allison M. LaRocco

  • Kirsten E. Lyke

  • Sarah M. Litts

  • Shrimati Datta

  • Yuanyuan Liang

  • Megan F. McGilvray

  • Jeannie A. Losignor

  • Jennifer J. Oshinsky

  • Kari V. Palmer

  • Ifayet PL Johnson-Mayo

  • Gabrielle Scher

  • Uthra Balakumar

  • Anisha Chandwani

  • Rekha R. Rapaka

  • Meagan E. Deming

  • Joel V. Chua

  • Christoph Wirblich

  • Wilbur H. Chen

  • Kathleen M. Neuzil

  • Marcela F. Pasetti

  • Matthias J. Schnell

  • June 9, 2026

  • 0 min

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Objective:

To evaluate the safety and reactogenicity of the two-dose LASSARAB + aPHAD-SE vaccine series.

Key Findings:
  • The study enrolled 54 participants with a mean age of 32.5 years and a BMI of 25.3 kg/m².
  • 44.4% of participants were women, 13.0% were Black or African American, and 11.1% were Hispanic.
  • All participants completed safety and immunogenicity monitoring through day 61.
Interpretation:

The trial aims to assess the safety profile of the LASSARAB vaccine, which could address the urgent need for Lassa fever prevention.

Limitations:
  • The study involved a small sample size of 54 participants.
  • The trial was limited to healthy adults aged 18-50, which may not represent the broader population at risk.
Conclusion:

The interim analysis provides initial safety data for the LASSARAB vaccine, contributing to the development of preventive measures against Lassa fever.

Original Source(s)

Adjuvanted inactivated rabies virus-vectored Lassa virus vaccine in healthy adults: a phase 1 trial

  • by Justin R. Ortiz, Drishya Kurup, Adam C. Kaufman, Sabrine Ben Hamed, Allison M. LaRocco, Kirsten E. Lyke, Sarah M. Litts, Shrimati Datta, Yuanyuan Liang, Megan F. McGilvray, Jeannie A. Losignor, Jennifer J. Oshinsky, Kari V. Palmer, Ifayet PL Johnson-Mayo, Gabrielle Scher, Uthra Balakumar, Anisha Chandwani, Rekha R. Rapaka, Meagan E. Deming, Joel V. Chua, Christoph Wirblich, Wilbur H. Chen, Kathleen M. Neuzil, Marcela F. Pasetti, Matthias J. Schnell

  • June 9, 2026

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