To assess the effects of clinical pharmacist interventions on stabilizing tacrolimus blood concentrations in pediatric bone marrow transplantation, emphasizing the challenges of managing tacrolimus therapy.
Key Findings:
77.1% of pharmacist interventions were successfully resolved out of a total of 35 interventions.
The proportion of patients within the therapeutic range increased from 52.3% at baseline to 84.4% post-intervention and remained at 82.5% after 3 months (p < 0.001).
Caregivers and nurses showed significant and lasting improvements in pharmacological knowledge and medication-use behaviors (p < 0.001).
Elevated knowledge levels and unresolved DRPs were critical factors affecting tacrolimus stability (p < 0.05).
Interpretation:
Clinical pharmacist-led interventions significantly improve tacrolimus therapy management in pediatric bone marrow transplantation, highlighting the importance of education and DRP resolution for clinical practice.
Limitations:
The study was limited to five hospitals in Istanbul, which may affect generalizability and introduce potential biases.
The sample size of 65 pediatric patients may not represent the broader population, and confounding factors may not have been fully addressed.
Conclusion:
Clinical pharmacist interventions are essential for optimizing tacrolimus levels and enhancing patient safety in pediatric bone marrow transplantation, warranting further research to validate these findings.
