To identify early risk factors and temporal biomarker trends associated with Trousseau syndrome-related cerebral infarction (TSCI) in lung cancer patients.
Key Findings:
The model demonstrated good discrimination with an AUC of 0.861.
Fulminant TSCI exhibited significant abnormalities across multiple domains.
Early-onset TSCI was linked to higher levels of Ki67, neuron-specific enolase, and lactate dehydrogenase.
Late-onset TSCI was associated with elevated triglyceride levels.
Interpretation:
Remove unsupported conclusions about risk stratification.
Limitations:
The study is retrospective and may be subject to selection bias.
Further validation in independent prospective cohorts is needed to confirm generalizability.
Conclusion:
Revise to eliminate claims about the nomogram's utility and focus on findings.
