Anti-NMDAR and anti-MOG antibody double-positive encephalitis temporally associated with cytomegalovirus detection in cerebrospinal fluid: a case report - Summary - MDSpire

Anti-NMDAR and anti-MOG antibody double-positive encephalitis temporally associated with cytomegalovirus detection in cerebrospinal fluid: a case report

  • By

  • Rujue Guo

  • Qili Chen

  • Lingen Kong

  • Aizheng Huang

  • Yankun Li

  • Caiming Li

  • June 9, 2026

  • 0 min

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Objective:

To report the first case of overlapping syndrome (MNOS) with concomitant cytomegalovirus (CMV) infection detected in cerebrospinal fluid.

Key Findings:
  • CMV DNA was detected in CSF with high confidence.
  • Coexisting anti-NMDAR and anti-MOG antibodies were found in the CSF.
  • The patient's condition improved after treatment.
Interpretation:

The case highlights the potential link between viral infections and overlapping syndrome (MNOS).

Limitations:
  • Lack of detection of CMV-DNA in CSF by real-time PCR.
  • Absence of dynamic assessment of serum/CSF CMV IgG/IgM, anti-NMDAR, and MOG antibody titers.
Conclusion:

Clinical vigilance for coexisting autoimmune encephalitis should be heightened following viral infections.

Original Source(s)

Anti-NMDAR and anti-MOG antibody double-positive encephalitis temporally associated with cytomegalovirus detection in cerebrospinal fluid: a case report

  • by Rujue Guo, Qili Chen, Lingen Kong, Aizheng Huang, Yankun Li, Caiming Li

  • June 9, 2026

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