Pain-free survival after endoscopic neurotomy versus radiofrequency ablation of the C2 dorsal root ganglion for cervicogenic headache: a real-world comparison study - Summary - MDSpire

Pain-free survival after endoscopic neurotomy versus radiofrequency ablation of the C2 dorsal root ganglion for cervicogenic headache: a real-world comparison study

  • By

  • Yunjian Huang

  • Shiyun Xu

  • Siyi Liu

  • Wancheng Zheng

  • Zaiying Jiang

  • Xiangdong Wan

  • Xiangyu Zhang

  • Tao Du

  • Guang Lu

  • Bing Ni

  • Hongwei Zhu

  • June 8, 2026

  • 0 min

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Objective:

To compare long-term outcomes of endoscopic neurotomy (EN) versus radiofrequency ablation (RFA) targeting the C2 dorsal root ganglion in patients with cervicogenic headache (CEH), highlighting the significance of this comparison.

Key Findings:
  • Both EN and RFA groups showed significant reductions in NRS and improvements in EQ-5D-5L at 3 and 12 months postoperatively (P < 0.001).
  • NRS and EQ-5D-5L outcomes were comparable at 3 months (P > 0.05), but EN showed superior effectiveness at 12 months (P < 0.05).
  • PGIC favored EN at both 3 and 12 months (P < 0.05).
  • Median pain-free duration was significantly longer in the EN group (33 months) compared to the RFA group (8 months) (P < 0.05).
Interpretation:

Both EN and RFA improved pain and quality of life in CEH patients, with EN associated with longer pain-free duration; however, EN's invasiveness necessitates careful patient selection and consideration of potential risks.

Limitations:
  • The study is retrospective and conducted at a single center, which may limit generalizability.
  • The sample size for EN was relatively small (21 patients), which may affect the robustness of the findings.
  • Potential biases in patient selection and treatment allocation should be acknowledged, as well as confounding factors that may influence outcomes.
Conclusion:

EN may provide longer-lasting pain relief compared to RFA in CEH patients, but should be approached cautiously due to its invasive nature; further research is needed to validate these findings.

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