Plasma cytokine profiles in breast cancer patients and their association with therapeutic response in Peru: a prospective cohort study - Summary - MDSpire

Plasma cytokine profiles in breast cancer patients and their association with therapeutic response in Peru: a prospective cohort study

  • By

  • Jose M. Vela-Ruiz

  • Zaida Morante

  • Yomali Ferreyra

  • Marco A. Galvez-Villanueva

  • Fernando Valencia

  • J. Jhanina Campos-Tineo

  • Mariana Callapiña De Paz

  • Ariana Alessandra Córdova-Salazar

  • Pool Marcos-Carbajal

  • Joan M. Moreno Lujan

  • Andy R. Pantoja Lazaro

  • Laura G. Escobar Caipo

  • Gustavo A. Flores Trujillo

  • Teresa N. Cusma Quintana

  • Jhony A. De La Cruz-Vargas

  • Henry L. Gomez

  • Alonso Soto

  • June 9, 2026

  • 0 min

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Objective:

To characterize the plasma cytokine profile in Peruvian women with breast cancer, specifically focusing on molecular subtypes such as luminal A, luminal B, HER2-positive, and triple-negative, and evaluate its association with treatment response.

Key Findings:
  • Cytokine concentration differences were observed between breast cancer molecular subtypes, including MIP-1β, IL-9, GRO-α, and TNF-β.
  • Lower levels of circulating FGF BASIC were associated with an increased relative risk of achieving complete pathological response (pCR).
  • Decreased levels of FGF BASIC, PDGF BB, SDF-1, IL-12 P40, and IL-8 were linked to a higher chance of clinical responses to treatments.
  • Only FGF-BASIC, PDGF-BB, and IL-12 P40 remained independently associated with clinical response in multivariable analyses.
Interpretation:

The study identified specific plasma cytokines linked to breast cancer subtypes and treatment response in a Peruvian cohort, with FGF-BASIC showing a significant association that may inform treatment strategies.

Limitations:
  • The study was limited to a specific population in Peru, which may not be generalizable to other populations.
  • The sample size was relatively small, which may affect the robustness of the findings and introduce potential biases in sample collection or analysis.
Conclusion:

The findings enhance the understanding of the immunological mechanisms involved in breast cancer and identify potential prognostic biomarkers in this population.

Original Source(s)

Plasma cytokine profiles in breast cancer patients and their association with therapeutic response in Peru: a prospective cohort study

  • by Jose M. Vela-Ruiz, Zaida Morante, Yomali Ferreyra, Marco A. Galvez-Villanueva, Fernando Valencia, J. Jhanina Campos-Tineo, Mariana Callapiña De Paz, Ariana Alessandra Córdova-Salazar, Pool Marcos-Carbajal, Joan M. Moreno Lujan, Andy R. Pantoja Lazaro, Laura G. Escobar Caipo, Gustavo A. Flores Trujillo, Teresa N. Cusma Quintana, Jhony A. De La Cruz-Vargas, Henry L. Gomez, Alonso Soto

  • June 9, 2026

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