RSPO2-induced ferroptosis via PTBP1-mediated FSP1 mRNA decay suppresses breast cancer progression - Takeaways - MDSpire

RSPO2-induced ferroptosis via PTBP1-mediated FSP1 mRNA decay suppresses breast cancer progression

  • By

  • Shuyun Jiang

  • Hongwei Ma

  • Zhanwei Du

  • Zhijun Ma

  • Xiaowu Wang

  • June 9, 2026

  • 0 min

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  • 1

    RSPO2 expression is downregulated in malignant breast cancer tissues and is associated with breast cancer subtypes.

  • 2

    Restoring RSPO2 expression suppresses cell proliferation, migration, and invasion in vitro and inhibits tumor growth in vivo.

  • 3

    RSPO2 promotes PTBP1 ubiquitination and degradation, leading to decreased FSP1 mRNA stability and expression.

  • 4

    RSPO2 overexpression triggers ferroptosis, indicated by ROS accumulation, GSH depletion, and increased MDA and Fe2+ levels.

  • 5

    The RSPO2/PTBP1/FSP1 signaling axis is identified as a novel therapeutic target in breast cancer.

Original Source(s)

RSPO2-induced ferroptosis via PTBP1-mediated FSP1 mRNA decay suppresses breast cancer progression

  • by Shuyun Jiang, Hongwei Ma, Zhanwei Du, Zhijun Ma, Xiaowu Wang

  • June 9, 2026

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