Chelerythrine enhances anti-fungi immunity in Caenorhabditis elegans via DAF-16 and NHR-49 mediated fatty acid metabolism

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Chelerythrine significantly extends the lifespan of Caenorhabditis elegans infected with Candida albicans and inhibits C. albicans proliferation.
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The protective effect of Chelerythrine is mediated through the activation of the DAF-16/FoxO pathway and NHR-49-mediated fatty acid metabolism.
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Mutations in daf-16 and nhr-49 completely abolish the lifespan-extending effect of Chelerythrine in C. elegans.
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Chelerythrine treatment upregulates the expression of genes related to the FoxO pathway and fatty acid metabolism in C. elegans.
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Chelerythrine does not exhibit direct inhibitory activity against various bacterial pathogens, indicating it enhances immunity without suppressing pathogen growth.

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