Temporal transcriptomic analysis of scale drop disease virus in Asian seabass kidney cells reveals host immune and signaling changes

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Scale drop disease virus (SDDV) poses a significant threat to Asian seabass aquaculture, causing high mortality and economic losses.
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The study utilized a permissive ASB kidney cell model to investigate host transcriptional responses to SDDV infection over time.
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Time-resolved RNA sequencing revealed dynamic remodeling of immune signaling pathways and cellular processes during SDDV infection.
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Early infection stages showed rapid activation of innate immune responses, while later stages involved immune modulation and cellular reprogramming.
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The findings establish ASBK-1 cells as a valuable platform for studying SDDV pathogenesis and host-virus interactions.

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