Pathological triad of perioperative acute kidney injury: renal microcirculatory hypoxia, mitochondrial damage, and immuno-metabolic reprogramming - Takeaways - MDSpire

Pathological triad of perioperative acute kidney injury: renal microcirculatory hypoxia, mitochondrial damage, and immuno-metabolic reprogramming

  • By

  • Shenghua Li

  • Xiyan Wei

  • Xudong Han

  • Jingli Wang

  • Na Li

  • Jing Liu

  • Meiling Zhang

  • June 8, 2026

  • 0 min

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  • 1

    Perioperative acute kidney injury (AKI) is a common complication that increases mortality and prolongs hospital stays after surgery.

  • 2

    Traditional models focusing on systemic hemodynamic disturbances are inadequate for explaining AKI occurring with stable macro-parameters.

  • 3

    The article proposes a pathological triangle model involving renal microcirculatory hypoxia, mitochondrial dysfunction, and immunometabolic alterations.

  • 4

    This model emphasizes the interdependence of its components and their shifting dominance across different time windows.

  • 5

    A multidimensional stratification approach is suggested for assessing and managing perioperative AKI based on the proposed model.

Original Source(s)

Pathological triad of perioperative acute kidney injury: renal microcirculatory hypoxia, mitochondrial damage, and immuno-metabolic reprogramming

  • by Shenghua Li, Xiyan Wei, Xudong Han, Jingli Wang, Na Li, Jing Liu, Meiling Zhang

  • June 8, 2026

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