Long-term trends in the burden of leukemia subtypes in China from 1990 to 2021: a Joinpoint regression and age-period-cohort analysis based on GBD 2021 - Takeaways - MDSpire

Long-term trends in the burden of leukemia subtypes in China from 1990 to 2021: a Joinpoint regression and age-period-cohort analysis based on GBD 2021

  • By

  • Yudi Shangguan

  • Xinyue Gou

  • Yue Luo

  • Zhuo Chen

  • June 4, 2026

  • 0 min

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  • 1

    From 1990 to 2021, China saw 105,670 new leukemia cases, with acute lymphoblastic leukemia (ALL) having the highest burden among subtypes.

  • 2

    Chronic myeloid leukemia (CML) exhibited the greatest declines in incidence, deaths, and disability-adjusted life years (DALYs) compared to other subtypes.

  • 3

    Age-standardized incidence rates (ASIRs) for acute myeloid leukemia (AML) and CML declined, while ALL and chronic lymphocytic leukemia (CLL) showed increasing trends.

  • 4

    Age was identified as the primary determinant of leukemia incidence, with distinct age distributions and cohort patterns observed across the subtypes.

  • 5

    Future projections indicate stable rates for AML and CML, a gradual decline for ALL, and a continued rise for CLL through 2046, necessitating targeted strategies.

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