Repeated-dose toxicity and immunogenicity evaluation of norovirus P particle-based rotavirus vaccine in juvenile cynomolgus monkeys - Takeaways - MDSpire

Repeated-dose toxicity and immunogenicity evaluation of norovirus P particle-based rotavirus vaccine in juvenile cynomolgus monkeys

  • By

  • Wei Pan

  • Yingjie Cheng

  • Xiaojing Shi

  • Yunxiang Chen

  • Cong Xu

  • Zhengbiao Yang

  • Qijiong Lu

  • Lei Wen

  • Fang Liu

  • Tingli Bian

  • Li Qin

  • Shuizhen Pan

  • Ying Chen

  • Changwei Wu

  • Lijiang Zhang

  • Hongzhong Yang

  • June 9, 2026

  • 0 min

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  • 1

    The study evaluated the safety and immunogenicity of a bivalent rotavirus vaccine candidate in young cynomolgus monkeys.

  • 2

    Monkeys received four intramuscular injections of the vaccine at varying doses, with no significant toxicological abnormalities observed.

  • 3

    Histopathological findings indicated mild inflammatory reactions and aluminum hydroxide adjuvant deposition at the injection site.

  • 4

    Lymphoid follicle hyperplasia in draining lymph nodes confirmed a typical immune response to the aluminum adjuvant.

  • 5

    The findings support the safety and immunogenicity of the PP-P[6]/P[8]-VP8 Mix vaccine, paving the way for clinical research.

Original Source(s)

Repeated-dose toxicity and immunogenicity evaluation of norovirus P particle-based rotavirus vaccine in juvenile cynomolgus monkeys

  • by Wei Pan, Yingjie Cheng, Xiaojing Shi, Yunxiang Chen, Cong Xu, Zhengbiao Yang, Qijiong Lu, Lei Wen, Fang Liu, Tingli Bian, Li Qin, Shuizhen Pan, Ying Chen, Changwei Wu, Lijiang Zhang, Hongzhong Yang

  • June 9, 2026

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