Cellular expression domains of type 3 deiodinase in the meninges, choroid plexus, tanycytes and barrier tissues of the brain - Takeaways - MDSpire

Cellular expression domains of type 3 deiodinase in the meninges, choroid plexus, tanycytes and barrier tissues of the brain

  • By

  • Ye Liu

  • Lily Ng

  • Hong Liu

  • Douglas Forrest

  • June 8, 2026

  • 0 min

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  • 1

    Type 3 deiodinase (DIO3) is crucial for regulating thyroid hormone levels during brain development.

  • 2

    DIO3 expression was identified in non-neuronal cell types at blood-brain and blood-CSF barriers in mice.

  • 3

    DIO3 expression begins early in embryonic development, even before barrier functions mature.

  • 4

    The study utilized Dio3Cre-mediated cell labeling to visualize DIO3 expression in barrier tissues.

  • 5

    Findings suggest DIO3 plays a role in controlling thyroid hormone availability at critical brain interfaces.

Original Source(s)

Cellular expression domains of type 3 deiodinase in the meninges, choroid plexus, tanycytes and barrier tissues of the brain

  • by Ye Liu, Lily Ng, Hong Liu, Douglas Forrest

  • June 8, 2026

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