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1
POC1A is significantly upregulated in breast cancer tissues, showing potential as a biomarker with an AUC of 0.879 in the TCGA cohort.
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2
High POC1A expression correlates with larger tumor size and advanced clinical stage, identified as an independent risk factor for poor prognosis.
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3
Kaplan–Meier analysis indicates that high POC1A mRNA expression is associated with poorer survival outcomes in breast cancer patients.
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4
POC1A knockdown reduces cell proliferation, migration, and invasion in breast cancer cell lines, while overexpression enhances these malignant characteristics.
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5
Modulation of POC1A affects Wnt/β-catenin signaling and EMT-related markers, suggesting its role in promoting malignant phenotypes in non-triple-negative breast cancer.
