Association of serum selenium levels with inflammatory and oxidative stress markers in patients with post-infarction heart failure: an exploratory case-control study supported by in vitro mechanistic evidence - Takeaways - MDSpire

Association of serum selenium levels with inflammatory and oxidative stress markers in patients with post-infarction heart failure: an exploratory case-control study supported by in vitro mechanistic evidence

  • By

  • Fabrice Yves Ndjana Lessomo

  • Ruiyang Zhu

  • Jingjing Wan

  • Jinbo Zhao

  • Yuanhong Li

  • Ye Mao

  • Liping Guo

  • June 9, 2026

  • 0 min

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  • 1

    Selenium deficiency correlates with increased inflammatory markers (TNF-α, IL-6) and oxidative stress (MDA) in post-infarction heart failure patients.

  • 2

    Lower serum Selenium levels are associated with reduced antioxidant capacity (SOD) and impaired cardiac function (LVEF) in heart failure.

  • 3

    In vitro studies show that Selenium treatment decreases pro-inflammatory and pro-fibrotic gene expression in cardiomyocytes under stress.

  • 4

    Selenium distribution varies across heart failure phenotypes, indicating stage-dependent differences in oxidative stress and inflammation.

  • 5

    The findings suggest that serum Selenium may serve as a potential biomarker for inflammation and oxidative stress in heart failure.

Original Source(s)

Association of serum selenium levels with inflammatory and oxidative stress markers in patients with post-infarction heart failure: an exploratory case-control study supported by in vitro mechanistic evidence

  • by Fabrice Yves Ndjana Lessomo, Ruiyang Zhu, Jingjing Wan, Jinbo Zhao, Yuanhong Li, Ye Mao, Liping Guo

  • June 9, 2026

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