Efficacy and safety of Oliceridine versus Sufentanil in postoperative analgesia for burn skin grafting: a machine learning and SHAP-based cohort study - Takeaways - MDSpire

Efficacy and safety of Oliceridine versus Sufentanil in postoperative analgesia for burn skin grafting: a machine learning and SHAP-based cohort study

  • By

  • Ye Tian

  • Yun Zhang

  • Danshi Feng

  • Hongying Wang

  • Zihuan Ma

  • June 9, 2026

  • 0 min

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  • 1

    This study analyzed 586 patients undergoing burn skin grafting to compare the efficacy and safety of Oliceridine and Sufentanil.

  • 2

    Machine learning models predicted the need for rescue analgesia and postoperative nausea and vomiting, showing Oliceridine's efficacy similar to Sufentanil.

  • 3

    The XGBoost efficacy model identified total burn surface area and surgery duration as key predictors, with opioid choice having minimal impact.

  • 4

    Sufentanil administration and female gender were significant risk factors for postoperative nausea and vomiting in the cohort.

  • 5

    Oliceridine was associated with a lower predicted risk of postoperative nausea and vomiting compared to Sufentanil, suggesting a favorable safety profile.

Original Source(s)

Efficacy and safety of Oliceridine versus Sufentanil in postoperative analgesia for burn skin grafting: a machine learning and SHAP-based cohort study

  • by Ye Tian, Yun Zhang, Danshi Feng, Hongying Wang, Zihuan Ma

  • June 9, 2026

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