Effects of ciprofol versus propofol sedation on hypoxaemia and hypotension in elderly patients undergoing bidirectional endoscopy: protocol for a randomized controlled trial - Takeaways - MDSpire

Effects of ciprofol versus propofol sedation on hypoxaemia and hypotension in elderly patients undergoing bidirectional endoscopy: protocol for a randomized controlled trial

  • By

  • Yue Fei

  • Minjun Gu

  • Xinlong Li

  • Liangyu Zheng

  • Youjia Yu

  • Zhengjie Chen

  • June 9, 2026

  • 0 min

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  • 1

    This study compares ciprofol and propofol sedation effects on hypoxaemia and hypotension in elderly patients during gastrointestinal endoscopy.

  • 2

    A total of 184 patients aged ≥65 years will be randomly assigned to receive either ciprofol or propofol in a double-blind trial.

  • 3

    The primary outcome measures the composite incidence of hypoxaemia and hypotension during sedation in the study population.

  • 4

    Secondary outcomes include individual incidences of hypoxaemia and hypotension, sedation times, and patient satisfaction.

  • 5

    Ciprofol may offer improved cardiorespiratory stability compared to propofol, addressing concerns in elderly patients undergoing sedation.

Original Source(s)

Effects of ciprofol versus propofol sedation on hypoxaemia and hypotension in elderly patients undergoing bidirectional endoscopy: protocol for a randomized controlled trial

  • by Yue Fei, Minjun Gu, Xinlong Li, Liangyu Zheng, Youjia Yu, Zhengjie Chen

  • June 9, 2026

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