AKT-mediated phosphorylation of ZDHHC5 promotes NOD1 palmitoylation and innate immune signaling - Takeaways - MDSpire

AKT-mediated phosphorylation of ZDHHC5 promotes NOD1 palmitoylation and innate immune signaling

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1

AKT phosphorylates ZDHHC5 at Ser345 and Ser380, enhancing its activity and promoting NOD1 palmitoylation.
2

Growth factors and insulin positively regulate NOD1 activation through the AKT-ZDHHC5-NOD1 signaling axis.
3

NOD1 activation is crucial for initiating innate immune responses against bacterial peptidoglycan.
4

Disruption of AKT-dependent ZDHHC5 phosphorylation impairs NOD1 palmitoylation and downstream inflammatory signaling.
5

The AKT-ZDHHC5 pathway may serve as a target for modulating NOD1-driven inflammatory diseases.