Early risk stratification and temporal biomarker patterns of trousseau syndrome-related cerebral infarction in lung cancer - Takeaways - MDSpire

Early risk stratification and temporal biomarker patterns of trousseau syndrome-related cerebral infarction in lung cancer

  • By

  • Ziyi Xiao

  • Wenbo Zhang

  • Yikai Han

  • Jiaxin Pei

  • Yushu Deng

  • Mengmeng Yang

  • Feng Wang

  • Taiying Lu

  • June 9, 2026

  • 0 min

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  • 1

    Trousseau syndrome-related cerebral infarction (TSCI) is a severe complication of lung cancer with limited early risk stratification tools.

  • 2

    A five-variable model was developed to assess early risk factors for TSCI, showing good discrimination with an AUC of 0.861.

  • 3

    Fulminant TSCI exhibited significant abnormalities across coagulation, inflammatory, tumor-burden, and nutritional domains.

  • 4

    Temporal analyses revealed that early-onset TSCI correlated with higher levels of Ki67, neuron-specific enolase, and lactate dehydrogenase.

  • 5

    The proposed nomogram for TSCI risk assessment may aid in early risk stratification and clinical surveillance in lung cancer patients.

Original Source(s)

Early risk stratification and temporal biomarker patterns of trousseau syndrome-related cerebral infarction in lung cancer

  • by Ziyi Xiao, Wenbo Zhang, Yikai Han, Jiaxin Pei, Yushu Deng, Mengmeng Yang, Feng Wang, Taiying Lu

  • June 9, 2026

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