Anti-NMDAR and anti-MOG antibody double-positive encephalitis temporally associated with cytomegalovirus detection in cerebrospinal fluid: a case report - Takeaways - MDSpire

Anti-NMDAR and anti-MOG antibody double-positive encephalitis temporally associated with cytomegalovirus detection in cerebrospinal fluid: a case report

  • By

  • Rujue Guo

  • Qili Chen

  • Lingen Kong

  • Aizheng Huang

  • Yankun Li

  • Caiming Li

  • June 9, 2026

  • 0 min

Share

  • 1

    The case study reports the first instance of overlapping syndrome (MNOS) with coexisting anti-NMDAR and anti-MOG antibodies and cytomegalovirus (CMV) infection.

  • 2

    A 49-year-old man presented with fever and neuropsychiatric symptoms, leading to the diagnosis of MNOS after cerebrospinal fluid analysis.

  • 3

    Metagenomic next-generation sequencing confirmed the presence of CMV DNA in the cerebrospinal fluid, with a high relative abundance.

  • 4

    The patient showed positive anti-NMDAR and anti-MOG antibodies in cerebrospinal fluid, while only anti-MOG antibodies were detected in serum.

  • 5

    Treatment included antiviral agents, corticosteroids, and intravenous immunoglobulin, resulting in gradual improvement of the patient's condition.

Original Source(s)

Anti-NMDAR and anti-MOG antibody double-positive encephalitis temporally associated with cytomegalovirus detection in cerebrospinal fluid: a case report

  • by Rujue Guo, Qili Chen, Lingen Kong, Aizheng Huang, Yankun Li, Caiming Li

  • June 9, 2026

Related Content

Understanding stroke caregiving in rural contexts: a qualitative study of family caregivers’ cultural values, coping behaviors, and technology use

Stroke Severity Linked to Dementia Risk

Findings support greater attention to stroke prevention and poststroke cognitive monitoring.

Nurses Face High Physical, Cognitive Load in Trauma Surgery

Qualitative interviews identified four themes involving emergency challenges and response, teamwork, psychological stress and coping, and professional growth needs in trauma surgery.