The impact of regressed endometrial hyperplasia on reproductive outcomes following frozen embryo transfer: a propensity score-matched cohort study - Takeaways - MDSpire

The impact of regressed endometrial hyperplasia on reproductive outcomes following frozen embryo transfer: a propensity score-matched cohort study

  • By

  • Qinling Zhu

  • Lizhen Xu

  • Bing Xu

  • Yao Lu

  • Zhe Wei

  • Wenchao Zhang

  • Yiwen Meng

  • Chongwen Shao

  • Mengjia Shi

  • Yaqiong He

  • Jiangan Huang

  • Yuan Wang

  • Jia Qi

  • Ying Ding

  • Yun Sun

  • June 8, 2026

  • 0 min

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  • 1

    Patients with regressed endometrial hyperplasia (EH) had a significantly lower live birth rate compared to matched controls (31.6% vs. 49.2%, P = 0.002).

  • 2

    The clinical pregnancy rate was also reduced in EH patients (44.2%) compared to controls (59.2%, P = 0.008), indicating impaired reproductive outcomes.

  • 3

    EH patients experienced a higher pregnancy loss rate (40%) than controls (26.1%, P = 0.046), further highlighting reproductive challenges.

  • 4

    Subgroup analysis revealed a marginally lower live birth rate in EH patients with atypia compared to those without atypia.

  • 5

    Logistic regression identified that EH with atypia, prolonged progesterone treatment, and delayed remission were associated with a reduced likelihood of live birth.

Original Source(s)

The impact of regressed endometrial hyperplasia on reproductive outcomes following frozen embryo transfer: a propensity score-matched cohort study

  • by Qinling Zhu, Lizhen Xu, Bing Xu, Yao Lu, Zhe Wei, Wenchao Zhang, Yiwen Meng, Chongwen Shao, Mengjia Shi, Yaqiong He, Jiangan Huang, Yuan Wang, Jia Qi, Ying Ding, Yun Sun

  • June 8, 2026

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