Risk of disseminated tuberculosis and other infections after neonatal Bacillus Calmette–Guérin vaccination in infants with in-utero exposure to tumor necrosis factor-α inhibitors - Takeaways - MDSpire

Risk of disseminated tuberculosis and other infections after neonatal Bacillus Calmette–Guérin vaccination in infants with in-utero exposure to tumor necrosis factor-α inhibitors

  • By

  • Samar Al Emadi

  • Seham Alebbi

  • Nawal Hadwan

  • Omar Alsaed

  • Priyanka Moovara Cackamvalli

  • Nevin Abunahia

  • Eman Satti

  • June 8, 2026

  • 0 min

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  • 1

    Infants exposed to TNF-α inhibitors in utero were evaluated for the safety of BCG vaccination at birth.

  • 2

    Of 63 infants studied, 49 received BCG vaccination within the first year, with 27 vaccinated at birth.

  • 3

    Most infants vaccinated at birth were exposed to TNF-α inhibitors during the third trimester.

  • 4

    Over half of the infants experienced multiple infections, but none developed disseminated tuberculosis.

  • 5

    The study concluded that BCG vaccination at birth did not increase the risk of infection or hospitalization.

Original Source(s)

Risk of disseminated tuberculosis and other infections after neonatal Bacillus Calmette–Guérin vaccination in infants with in-utero exposure to tumor necrosis factor-α inhibitors

  • by Samar Al Emadi, Seham Alebbi, Nawal Hadwan, Omar Alsaed, Priyanka Moovara Cackamvalli, Nevin Abunahia, Eman Satti

  • June 8, 2026

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