Analysis of factors that increase serum progesterone levels on the day of hCG administration in gonadotropin-releasing hormone antagonist cycles

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The study analyzed 1392 IVF-ET and ICSI cycles to identify factors influencing serum progesterone levels on hCG administration day.
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Patients were divided into normal (NP) and high progesterone (HP) groups based on a cutoff of 1.5 ng/mL on hCG day.
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Key factors associated with elevated progesterone included BMI, basal progesterone, hCG-day serum E2 and LH levels, and total oocytes retrieved.
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Multivariate analysis confirmed BMI as a protective factor, while basal progesterone and hCG-day hormone levels were independent risk factors.
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The findings aim to assist clinicians in managing progesterone levels to improve reproductive outcomes during controlled ovarian stimulation.

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