Investigating the Influence of Apelin and Ghrelin in Multiple Sclerosis: A Study of Patients Undergoing Immunomodulatory Treatment - Takeaways - MDSpire

Investigating the Influence of Apelin and Ghrelin in Multiple Sclerosis: A Study of Patients Undergoing Immunomodulatory Treatment

  • By

  • Bożena Adamczyk

  • Natalia Morawiec

  • Michał Rakoca

  • Agata Sowa

  • Ksawier Sawa

  • Monika Adamczyk-Sowa

  • April 28, 2026

  • 0 min

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  • 1

    The study evaluated apelin and ghrelin levels in patients with relapsing-remitting multiple sclerosis undergoing immunomodulatory treatment.

  • 2

    Natalizumab-treated patients exhibited significantly higher apelin levels compared to healthy controls, while fingolimod-treated patients had higher ghrelin levels.

  • 3

    In women with MS, ghrelin levels increased with disease duration, indicating a potential link between hormone levels and disease progression.

  • 4

    Apelin levels positively correlated with BMI in the fingolimod-treated group, suggesting a relationship between metabolic factors and hormone regulation.

  • 5

    The findings suggest that immunomodulatory treatments may influence peptide hormone regulation, impacting metabolic factors in multiple sclerosis.

Original Source(s)

Investigating the Influence of Apelin and Ghrelin in Multiple Sclerosis: A Study of Patients Undergoing Immunomodulatory Treatment

  • by Bożena Adamczyk, Natalia Morawiec, Michał Rakoca, Agata Sowa, Ksawier Sawa, Monika Adamczyk-Sowa

  • April 28, 2026

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