FGF7 mitigates airway inflammation and epithelial injury in cigarette smoke-induced COPD model - Takeaways - MDSpire

FGF7 mitigates airway inflammation and epithelial injury in cigarette smoke-induced COPD model

  • By

  • Xinji Gong

  • Jingwen Li

  • Haitao Wang

  • Xi Luo

  • Xinying Hu

  • Jie Shen

  • Wenting Jia

  • Qiufeng Wan

  • Shareli Caikai

  • Zhijin Guo

  • Fang Yan

  • Ying Zhang

  • Feng Sun

  • Sicheng Xu

  • June 8, 2026

  • 0 min

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  • 1

    FGF7 levels are increased in lung tissues of COPD patients but decreased in serum samples.

  • 2

    In a COPD rat model, FGF7 administration improved lung function and reduced inflammation and fibrosis.

  • 3

    Knockdown of FGF7 exacerbated airway inflammation and tissue damage in the COPD model.

  • 4

    FGF7 activates key signaling pathways, including ADAM17-dependent EGFR/ERK1/2, p38, and PI3K/AKT.

  • 5

    FGF7 shows potential as a therapeutic target for preventing airway remodeling in COPD.

Original Source(s)

FGF7 mitigates airway inflammation and epithelial injury in cigarette smoke-induced COPD model

  • by Xinji Gong, Jingwen Li, Haitao Wang, Xi Luo, Xinying Hu, Jie Shen, Wenting Jia, Qiufeng Wan, Shareli Caikai, Zhijin Guo, Fang Yan, Ying Zhang, Feng Sun, Sicheng Xu

  • June 8, 2026

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